SiO2 with carboxyl (COOH) surface groups for the covalent attachment of biomolecules (see TechNote 104). Carboxyl silica microspheres are sold in 1.0g amounts. Supplied dry, they are available in four nominal mean diameters: ~0.5µm, ~1.0µm, ~2.0µm, and ~5.0µm.

*Please note: If you are NOT ordering via website, please specify a lot number if multiple lots are available.  
Catalog Number Nominal Diameter Specification Range Product Data Sheet Safety Data Sheet
SC03000 0.5µm

0.46 - 0.54µm

PDS 702.pdf SDS SG141.pdf
SC04000 1.0µm 0.95 - 1.05µm PDS 702.pdf SDS SG141.pdf
SC05000 2.0µm 2.80 - 2.20µm PDS 702.pdf SDS SG141.pdf
SC05001 5.0µm 4.80 - 5.20µm PDS 702.pdf SDS SG141.pdf


Wang L, Yang C, Tan W. (2004) Dual-luminophore-doped silica nanoparticles for multiplexed signaling. Nano Lett; 5(1):37-43.

Lauer, SA, Nolan, JP (2002) Development and characterization of Ni-NTA-bearing microspheres. Cytometry, 48: 136–145.

Yoo CE, Moon HS, Kim YJ, Park JM, Park D, Han KY,…Park WY (2015) Highly dense, optically inactive silica microbeads for the isolation and identification of circulating tumor cells. Biomaterials Jan;75:271-8.  (CTC isolation via anti-EpCAM coated silica microspheres)

Litvinov, J, Moen, S. T, Koh, CY, & Singh, AK (2016). Centrifugal sedimentation immunoassays for multiplexed detection of enteric bacteria in ground water. Biomicrofluidics, 10(1), 014103.(5µm carboxyl silica microspheres)

Litvinov J, Moen ST, Berry GJ, Loeffelholz M, Singh AK, & Koh CY. (2017). Centrifugal Microfluidic Platform for Rapid, Multiplexed Detection of TB and HIV Biomarkers in Whole Blood Samples. Journal of Bioengineering & Biomedical Science, 6(SAND-2015-11159J).(SC05001, 5µm Silica-COOH microspheres)

Iswardy E, Tsai TC, Cheng IF, Ho TC, Perng GC, & Chang HC. (2017). A bead-based immunofluorescence-assay on a microfluidic dielectrophoresis platform for rapid dengue virus detection. Biosensors and Bioelectronics, 95, 174-180.(Anti-flavivirus antibody coupled to 1µm Silica COOH [Cat. SC04000] via PolyLink Coupling Kit [Cat. PL01N])