Microspheres are routinely coated with ligands such as antibodies, oligonucleotides, and peptides, for use in diagnostics and bioseparations. Carboxyl- and amine-modified microspheres require the use of a chemical linker for activation and covalent immobilization of ligand. DEPC-Carbodiimide (EDAC) and Glutaraldehyde are two of the most common crosslinkers used in bead coating protocols. To purchase as a kit, see our coupling kits.

EDAC is a zero-length crosslinker that is routinely used for the covalent binding of amine-containing ligands to carboxylated microspheres.


Glutaraldehyde is a homobifunctional linker that is suitable for binding amine-containing ligands to amine-modified beads.

Catalog Number Description Volume Product Data Sheet Safety Data Sheet
AA010-1 DEPC - Carbodiimide (EDAC) 1g PDS 740.pdf SDS AR400.pdf
AA010-5 DEPC - Carbodiimide (EDAC) 5g PDS 740.pdf SDS AR400.pdf
AA012 Glutaraldehyde, EM Grade, 25% 10 × 10mL (ampoules) PDS 740.pdf SDS AR401.pdf