Microspheres are routinely coated with ligands such as antibodies, oligonucleotides, and peptides, for use in diagnostics and bioseparations. Carboxyl- and amine-modified microspheres require the use of a chemical linker for activation and covalent immobilization of ligand. DEPC-Carbodiimide (EDAC) and Glutaraldehyde are two of the most common crosslinkers used in bead coating protocols.
EDAC is a zero-length crosslinker that is routinely used for the covalent binding of amine-containing ligands to carboxylated microspheres.
Glutaraldehyde is a homobifunctional linker that is suitable for binding amine-containing ligands to amine-modified beads.
|Catalog Code||Description||Volume||Product Data Sheet||Safety Data Sheet|
|AA010||DEPC - Carbodiimide (EDAC)||1g & 5g||PDS 740.pdf||SDS AR400.pdf|
|AA012||Glutaraldehyde, EM Grade, 25%||10 × 10mL (ampoules)||PDS 740.pdf||SDS AR401.pdf|